Resveratrol is a wine phenolic that is known to interact with sirtuin proteins (mostly SIRT1) which is similar to leucine; the metabolites of KIC and HMB at are able to induce SIRT1 to 30-100% of baseline which is a comparable potency to 2-10μM resveratrol  although the combination of leucine () or HMB (μM) and resveratrol (200nM) is able to synergistically induce SIRT1 and SIRT3 activity in both adipocytes and skeletal muscle cells.  KIC appears to be a more potent stimulator than HMB,  and synergism appears to be greater with leucine than with HMB (possibly indicative of KIC metabolism). 
New and exciting research is still being conducted on BCAAs and their applications to muscle growth, fat loss, and performance. There are not many supplements in existence that have the ability to affect growth and performance through as many different pathways as BCAAs. While BCAAs have proven benefits as a building block of muscle tissue, their benefits as signaling molecules are truly just being understood. In time BCAAs may just prove to be the most valuable supplement at our disposal. So the next time someone accuses you of being just another meathead talking about protein all the time, you can show them that it is more than just eating plates of chicken and beef…it’s science!