Hormona secosteroide

在本发明的方法中,NADH或NADPH被用作辅因子。 In the method of the present invention, NADH or NADPH is used as a cofactor. 术语"NADP" 理解为烟酰胺腺嘌呤二核苷酸》粦酸,"NADPH"理解为还原型烟酰胺A泉嘌呤二核苷酸磷酸。 The term "NADP" is understood to nicotinamide adenine dinucleotide "lin acid," NADPH "understood as reduced nicotinamide A spring purine dinucleotide phosphate. 术语"NAD"表示烟酰胺腺噪呤二核苷酸,术语"NADH" 表示还原型烟酰胺腺嘌呤二核苷酸。 The term "NAD" indicates noise methotrexate gland nicotinamide dinucleotide, the term "NADH" indicates reduced nicotinamide adenine dinucleotide.

[0043] 在另一个方面,根据本发明通过通式I的开环二酮衍生物的对映体选择性酶促还原方法实现上述目的,其中在NADH或NADPH作为辅因子存在的条件下开环二酮衍生物被氧化还原酶/脱氢酶还原,该方法的特征在于所述氧化还原酶/脱氢酶长度为230到260个氨基酸,并包括选自[序列SEQ ID NO:18到SEQ ID NO:42]: [0043] In another aspect, the present invention achieves the above object is achieved by selective enzymatic reduction of Formula I enantiomer dione derivative of ring-opened, wherein NADH or NADPH as a cofactor ring opening under conditions existing diketone derivative is an oxidoreductase / dehydrogenase reduction, the method characterized by the oxidoreductase / dehydrogenase in length from 230 to 260 amino acids, and include those selected from [sequence SEQ ID NO: 18 to SEQ ID NO: 42]:

Hormona secosteroide

hormona secosteroide

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hormona secosteroide

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