Hypothalamic pituitary adrenal axis steroids

The circadian pattern of cortisol release is controlled by the suprachiasmatic nucleus (SCN) of the hypothalamus, also known as the body clock. Nerve signals from the SCN cause the paraventricular nucleus (PVN) of the hypothalamus to release pulses of CRH roughly once per hour, resulting in HPA axis activation and cortisol release. There are also direct links between the SCN and the adrenal gland itself (bypassing the HPA axis) through sympathetic nerve fibres, causing the adrenal gland to become more sensitive to ACTH stimulation during the morning, further adding to the circadian pattern of cortisol release throughout the day.

I am thinking of trying intermittent fasting and more exercise in the hope that my period will (a) stop completely (probably too much to hope for) or (b) decrease to a more manageable level. I currently don’t exercise much except for a 45 min walk 5 times a week. So I have room for improvement there too. I am worried that if I fast I’ll lose weight and I am currently in the “underweight” range of the BMI chart (possibly a side effect of medication) but I was always in the lower end of the “normal” range.
Over the past 3 years my periods have got so bad – heavy bleeding, severe cramps, migraines, vomiting, nausea that I just want them to stop.
Fortunately at the moment I am on Zoladex which has stopped my periods (and given me other side effects) but my doctor said I can only stay on it for 6 months max and then she’s hoping my hormones will “reset” themselves…

FSH and LH are secreted by the anterior pituitary in response to gonadotropin-releasing hormone (GNRH) secreted by the hypothalamus. In both males and females, FSH and LH secretion is regulated by a balance of positive and negative feedback mechanisms involving the hypothalamic-pituitary axis, the reproductive organs, and the pituitary and sex steroid hormones. FSH and LH play a critical role in maintaining the normal function of the male and female reproductive systems. Abnormal FSH levels with corresponding increased or decreased levels of LH, estrogens, progesterone, and testosterone are associated with a number of pathological conditions. Increased FSH levels are associated with menopause and primary ovarian hypofunction in females and primary hypogonadism in males. Decreased levels of FSH are associated with primary ovarian hyper-function in females and primary hypergonadism in males. Normal or decreased levels of FSH are associated with polycystic ovary disease in females. In males, LH is also called interstitial cell-stimulating hormone (ICSH). Abnormal LH levels with corresponding increased or decreased levels of FSH, estrogens, progesterone, and testosterone are associated with a number of pathological conditions. Increased LH levels are associated with menopause, primary ovarian hypofunction, and polycystic ovary disease in females and primary hypo-gonadism in males. Decreased LH levels are associated with primary ovarian hyperfunction in females and primary hyper-gonadism in males.

Hypothalamic pituitary adrenal axis steroids

hypothalamic pituitary adrenal axis steroids

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