New ocular steroid

Pharmacokinetics can be altered by using the “inactive metabolite approach” 26, 27, 28 in which one can design a soft analog of a drug that is active at the site of action but undergoes a one-step predicted metabolism in the circulation and will be transformed to the inactive metabolite from which its creation had been started 29 .  This process happens after the drug achieves its therapeutic role at the site of action and thus prevents the rest of the body to be exposed to the active drug or to various active or reactive metabolic products.

* Malignant Melanoma: This is another form of skin cancer often observed by optometrists. Malignant melanomas can appear in the choroid, the iris or even the conjunctiva. Malignant means that the tumor has the potential to metastasize. Melanoma shows that it arises from the pigmented cells of the eye. Because the choroid has the highest blood flow of any structure in the body and is considered part of the uveal tract, which also includes the iris and sclera, these tumors can often be aggressive. In fact, malignant melanomas of the choroid are the most common intraocular malignancy present. 17

Uveitis is another complication of herpes infections that may present after the initial visit. Ensure that the patient is taking the maximum oral antiviral therapy with good compliance. If uveitis appears, there can be a rapid development of inflammation that requires aggressive treatment. A loading dose of topical Pred Forte (prednisolone acetate 1%, Allergan) given every 15 minutes for a few hours, followed by a week of hourly dosing, is a reasonable start. Cycloplegia with a long-acting agent, such as homatropine 5%, is necessary. As with potential corneal scarring, seek subspecialty consultation if herpes associated uveitis is slow to resolve.

Retisert is a dramatic breakthrough in the treatment of chronic non-infectious posterior uveitis. It contains a small drug source of a corticosteroid agent, called fluocinole acetonide; the well-known steroid is slowly delivered and sustained for approximately years. This is the first consistent long-term intravitreal implant for posterior segment uveitis. Retisert is surgically implanted into the back of the eye and begins managing inflammation immediately. It is a safer alternative to the systemic, potentially toxic drugs that treat ocular inflammation.

New ocular steroid

new ocular steroid

Retisert is a dramatic breakthrough in the treatment of chronic non-infectious posterior uveitis. It contains a small drug source of a corticosteroid agent, called fluocinole acetonide; the well-known steroid is slowly delivered and sustained for approximately years. This is the first consistent long-term intravitreal implant for posterior segment uveitis. Retisert is surgically implanted into the back of the eye and begins managing inflammation immediately. It is a safer alternative to the systemic, potentially toxic drugs that treat ocular inflammation.

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