Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoeitic stimulating factor. During exogenous administration of androgens,Â endogenous testosterone Â release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH).
Anticoagulants: Patients on anticoagulants such as warfarin should be carefully monitored during anabolic steroid therapy as anabolic steroids may increase sensitivity to oral anticoagulants which may require a concomitant reduction in anticoagulant dosage to achieve a desirable prothrombin time (PT). Anticoagulant patients should be monitored regularly during anabolic steroid therapy, particularly during initiation and termination of therapy. Warfarin patients should have INR and PT monitored throughout androgen therapy and warfarin dosages titrated to achieve the desired INR and PT. Such patients should be monitored for occult bleeding.
Legal Anavar is the legal version of Anavar. Although Anavar is fairly mild when it comes to side effects, it can still injure the user. Many users report not suffering from side effects as much as they do with other steroids. However, it may cause disturbances in cholesterol levels and cause or exacerbate acne. It is generally well tolerated by women, and very few develop deeper voices, enlarge clitorises, or hirsutism. In fact, some users have even referred to it as a “girl steroid” because relatively few women suffer its side effects. Other steroids present more risk of masculinaizing features.