Steroid refractory chronic gvhd

Webster and Walker (2006) examined the safety and effectiveness of prolonged low-dose, continuous intravenous (IV) or subcutaneous ketamine infusions in non-cancer outpatients.  A total of 13 outpatients with neuropathic pain were administered low-dose IV or subcutaneous ketamine infusions for up to 8 weeks under close supervision by home health care personnel.  Using the 10-point VAS, 11 of 13 patients (85 %) reported a decrease in pain from the start of infusion treatment to the end.  Side effects were minimal and not severe enough to deter treatment.  Prolonged analgesic doses of ketamine infusions were safe for the small sample studied.  The authors concluded that these findings demonstrate that ketamine may provide a reasonable alternative treatment for non-responsive neuropathic pain in ambulatory outpatients.  Moreover, the authors stated that additional studies should follow to ascertain optimal dose and duration for specific pain disorders and to minimize side effects.  They also noted that questions regarding which patients would be most susceptible to this type of therapy and when treatment should be instituted remain unanswered. 

Recent scientific evidences are pointing out that an infectious agent(s) may play an important role in the pathophysiology of certain neuropsychiatric disorders in children 1,11,17,19,20 . Group A beta-hemolytic Streptococcus (GABS), and (possibly) other microorganisms (bacteria and viruses) have been implicated as causative agents in the ethiology of at least some cases of Obsessive Compulsive Disorders in children 1,8,19,20 , tic disorders (including Tourette's) 1,18,19,20 , Autistic Spectrum Disorders 10 and Anorexia Nervosa 17 . Presumed pathophysiological mechanisms are likely based on neurotropic auto immune antibody injury to the neurons 20 .

AB - Patients with steroid-resistant acute graft versus host disease (aGVHD) have a dismal prognosis, with mortality rates in excess of 90. We sought to identify a subgroup of patients less likely to benefit from initial therapy with corticosteroids as well as the impact of response on day 14 on outcome. Retrospective evaluation was performed of patients with biopsy-proven aGVHD treated with corticosteroids after allogeneic HSCT at . Anderson Cancer Center from 1998 through 2002 (N = 287). Overall response to first-line therapy on day 14 was 56. Grade III-IV aGVHD and hyperacute GVHD were the most significant factors predicting failure. Patients who fail to respond to steroids by day 14 should be considered for clinical trials. Severity of aGVHD, hyperacute GVHD, and sex mismatch could be integrated into prognostic scoring systems which may allow for pretreatment identification of patients unlikely to benefit from standard therapy with corticosteroids.

Dear sir,
Thanks a lot. I am really inspired with your efforts to remove quite a lots of misconceptions about Homeopathy in general public. Many Leading Homeo drs are least interested in educating people about this. Many times i have asked my doctor ( one of the leading homeo dr in my city) and he says that it is out of jealousy people are spreading this propaganda. But my question is what is your effort in preventing this spread of false propaganda. Anyway i am really happy that, though you are always a busy person, but when approached- very mild, scientific tempered and matured person. May god give you more and more strength to spread homeopathy in a scientific spirit.

Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:   18 Years and older   (Adult, Senior) Sexes Eligible for Study:   All Accepts Healthy Volunteers:   No Criteria Inclusion Criteria:

Steroid-induced osteoporosis (SIOP) is osteoporosis arising due to use of glucocorticoids (steroid hormones) - analogous to Cushing's syndrome and involving mainly the axial skeleton. The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Bisphosphonates are beneficial in reducing the risk of vertebral fractures. [1] Some professional guidelines recommend prophylactic calcium and vitamin D supplementation in patients who take the equivalent of more than 30 mg hydrocortisone ( mg of prednisolone), especially when this is in excess of three months. [2] [3] The use of thiazide diuretics, and gonadal hormone replacement has also been recommended, with the use of calcitonin, bisphosphonates, sodium fluoride or anabolic steroids also suggested in refractory cases. [4] Alternate day use may not prevent this complication. [5]

Steroid refractory chronic gvhd

steroid refractory chronic gvhd

Dear sir,
Thanks a lot. I am really inspired with your efforts to remove quite a lots of misconceptions about Homeopathy in general public. Many Leading Homeo drs are least interested in educating people about this. Many times i have asked my doctor ( one of the leading homeo dr in my city) and he says that it is out of jealousy people are spreading this propaganda. But my question is what is your effort in preventing this spread of false propaganda. Anyway i am really happy that, though you are always a busy person, but when approached- very mild, scientific tempered and matured person. May god give you more and more strength to spread homeopathy in a scientific spirit.

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